CHLORAMBUCIL:

Chlorambucilis a nitrogen mustard alkylating agentand is a vital medication which performs as a chemotherapy drug. Used for treating chronic lymphocytic leukemia, its generic name is Chlorambucil-Oral and has the ability to be administered orally. The brand name for Chlorambucil is Leukeran with its chemical formula derived from 4-[bis(2-chlorethyl)amino]benzenebutanoic acid and is available in a strength of 2mg.

Some of the side effects that may occur are:
 Gastrointestinal disorders such as ulcerations, nausea, diarrhea and/or vomiting
 Risk of other cancers that may develop
 Distress to the central nervous system involving hallucinations, agitation, ataxia, tremors, twitching of muscles and/or seizures
 Bone marrow suppression such as thrombocytopenia, anemia and neutropenia
 Loss of hair
 Hepatotoxicity
 Skin rashes
 Decrease in blood cells (Follow up lab tests are crucial)
 Causes harm to unborn fetus
 Causes disruption of the menstrual cycle
 Disturbs sperm production
 Pregnancy should not be planned while under treatment.

Vital precautions to follow while taking Chlorambucil:
One of the important things to do is to tell your doctor if you have any allergic reactions to drugs containing alkylating agents and to Chlorambucil. Any other drugs, vitamins or supplements which are taken should be discussed with the doctor. The doctor should be told if the patient has had any head injury, seizures and if radiation or other chemotherapy procedure has taken place. The doctor must know if the patient is breast feeding. Vaccinations should not be taken unless this is discussed with the doctor. Pregnancy should not be planned when under treatment involving Chlorambucil.

Indications:
Chlorambucil has been prescribed for treatment of trophoblastic neoplasms,non-Hodgkin lymphoma, ovarian carcinoma and Waldenströmmacroglobulinemia. Besides this, Chlorambucil has been used for cases suffering from Nephrotic syndromeincluding other inflammatoryand autoimmune conditions.

Dosage:
Depending on the condition, the doctor may prescribe oral intake of Chlorambucil with the dosage for Chronic Lymphatic (Lymphocytic) Leukemiastarting with0.1 mg/kg/day for 3-6 weeks which may be increased to 0.4 mg/kg according to symptoms or reactions. In case of Hodgkin's Lymphoma the dosage would be 0.2 mg/kg/day for 3-6 weeks and may be increased to 0.4 mg/kg (increased by 0.1 mg/kg/dose according to the reaction and/or efficient result.